ChloroquineV1, Main, Exploration, bibRecord, 001769

Jessner–Kanof disease induced by leflunomide: a dermal variant of cutaneous lupus?

Identifieur interne : 001769 ( Main/Exploration ); précédent : 001768; suivant : 001770

Jessner–Kanof disease induced by leflunomide: a dermal variant of cutaneous lupus?

Auteurs : Laëtitia Sparsa [France] ; Naji Afif [France] ; Joëlle Goetz [France] ; Christelle Sordet [France] ; Emmanuel Chatelus [France] ; Dan Lipsker [France] ; Jean Sibilia [France]

Source :

Rheumatology International [ 0172-8172 ] ; 2009-10-13.

RBID : Hal:hal-00561306

Abstract

Leflunomide can have adverse effects, but cases of subacute cutaneous lupus have more rarely been described. This drug, through its immunomodulatory effect, can favor the appearance of a Th2 lymphocyte immune response inducing lupus. A recent study has suggested that Jessner–Kanof disease (JKD) could be a dermal form of lupus. We report a case of subacute cutaneous lupus induced by leflunomide with anti-Ro/SSA Ab and unusual histological presentation, identical to that of JKD. Leflunomide can induce cutaneous lupus characterized by exclusively dermal involvement and histologically comparable to JKD. This observation therefore suggests that JKD could be a dermal variant of lupus. This prompted a revision of the classification of cutaneous lupus, which has until now been divided into acute, subacute and chronic forms but could equally be classed as epidermal, dermal and hypodermal. The last point of interest in our observation is the efficacy of a combination of chloroquine and anakinra, which led to complete remission of the articular and cutaneous symptoms after the failure of corticotherapy.

Url:

https://hal.archives-ouvertes.fr/hal-00561306

DOI: 10.1007/s00296-009-1169-z

Affiliations:

France

Links toward previous steps (curation, corpus...)

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to stream Hal, to step Curation: 000146
to stream Hal, to step Checkpoint: 000197
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to stream Main, to step Curation: 001769

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Leflunomide can have adverse effects, but cases of subacute cutaneous lupus have more rarely been described. This drug, through its immunomodulatory effect, can favor the appearance of a Th2 lymphocyte immune response inducing lupus. A recent study has suggested that Jessner–Kanof disease (JKD) could be a dermal form of lupus. We report a case of subacute cutaneous lupus induced by leflunomide with anti-Ro/SSA Ab and unusual histological presentation, identical to that of JKD. Leflunomide can induce cutaneous lupus characterized by exclusively dermal involvement and histologically comparable to JKD. This observation therefore suggests that JKD could be a dermal variant of lupus. This prompted a revision of the classification of cutaneous lupus, which has until now been divided into acute, subacute and chronic forms but could equally be classed as epidermal, dermal and hypodermal. The last point of interest in our observation is the efficacy of a combination of chloroquine and anakinra, which led to complete remission of the articular and cutaneous symptoms after the failure of corticotherapy.</p>
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Jessner–Kanof disease induced by leflunomide: a dermal variant of cutaneous lupus?

Jessner–Kanof disease induced by leflunomide: a dermal variant of cutaneous lupus?

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Abstract

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